SOLAR-Eclipse Genetics

Frequently Asked Questions

1. How do you build a pedigree file for SOLAR-Eclipse?

You can learn how to make a pedigree file by watching the video tutorials in the education section of this site. Once created, the new pedigree can be loaded and checked for errors using the load pedi my_pedi.csv command.

2. How do you perform heritability analyses using this software?

We have created a video tutorial demonstrating this as well in the education section. Also, see the options for the polygenic function. In general, once the trait is defined, running polygenic command will perform heritability analysis. Note, that if more than one trait is currently defined, polygenic command will perform pliotropy analysis.

3. When and where are SOLAR-Eclipse workshops held?

Typically, they are held annually at the International Imaging Genetics Conference in UC Irvine, California. Previously, there have also been talks given at the Organization of Human Brain Mapping meeting.

4. Can SOLAR-Eclipse only be downloaded in the linux version?

Currently, development is concentrated on the linux version of the software, but if you want the MacOS or Windows versions, then please contact us directly and we will compile the newest version for you.

5. Are there any quick ways of making the pedindex.out files tab-delimited so that it can be read onto other software easily?

See "help ped2csv"-- the pedindex file is a Pedsys formatted file with fixed column positions just like Fortran. There isn't any good way to convert to something else using standard Unix shell commands.

6. How do I perform multivariate genetic analysis?

Performing multivariate genetic analysis in SOLAR-Eclipse is simple. Define multiple traits using a single trait command e.g. "trait mytrait1 mytrait2." All follow up analysis such as polygenic, mga and multipoint will operate on the genetic variance shared by two or more traits.

7. How do I perform genetic association analysis?

There are multiple ways of performing this analysis in SOLAR-Eclipse. We are working on an education video describing this process. In the interim please see "mga". For a single snp association analysis, you can include it as a covariate and use "polygenic -s -all" command.

8. How do I perform QTL localization analysis?

We are working on the educational video explaining how to perform this analysis. In the interim, see instructions for the "multipoint" function.